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KMID : 0603519980030020128
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Journal of Korean Association of Cancer Prevention
1998 Volume.3 No. 2 p.128 ~ p.135
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Antimutagenic and Anticarcinogenic Effect of Sorghum
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Kweon Young-Mi
Park Kun-Young
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Abstract
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Antimutagenic effects of some cereals, legumes and oil seeds were studied using Ames test on Salmonella typhimurium TA 100. The methanol extracts of brown rice, sorghum, black seasame, white seasame, and Perilla seeds effectively inhibited the mutagenicity induced by aflatoxin Bl (AFBl). To separate and identify the antimutagenic and anticarcinogenic compounds from sorghum, the methanol extract was fractionated by using various solvents such as dichloromethane, ethylacetate and butanol. Among the solvent fractions from the methanol extract of sorghum, the dichloromethane fraction significantly reduced the mutagenicity induced by AFBl in Salmonella typhimurium TA 100. Using eukaryotic cells of C3H/10T1/2 cells, the anticarcinogenic effect of the methanol extract and the
dichloromethane fraction of sorghum was evaluated. It revealed that they inhibited the cytotoxicity of the MCA and reduced transformed foci induced by MCA.
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KEYWORD
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Sorghum, Antimutagenic, Anticarcinogenic, C3H/10T1/2 cells
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